Proverone
Brand names,
Proverone
Analogs
Proverone
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Proverone
Chemical_Formula
C22H32O3
Proverone
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Proverone
fda sheet
Proverone
msds (material safety sheet)
Proverone
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Proverone
Molecular Weight
344.488 g/mol
Proverone
Melting Point
220 - 223.5 oC
Proverone
H2O Solubility
22.2mg/L
Proverone
State
Solid
Proverone
LogP
3.606
Proverone
Dosage Forms
Tablets; Depo injection
Proverone
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Proverone
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Proverone
Absorption
Rapidly absorbed from GI tract
Proverone
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Proverone
Patient Information
Proverone
Organisms Affected
Humans and other mammals