Depo-Provera
Brand names,
Depo-Provera
Analogs
Depo-Provera
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Depo-Provera
Chemical_Formula
C22H32O3
Depo-Provera
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Depo-Provera
fda sheet
Depo-Provera
msds (material safety sheet)
Depo-Provera
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Depo-Provera
Molecular Weight
344.488 g/mol
Depo-Provera
Melting Point
220 - 223.5 oC
Depo-Provera
H2O Solubility
22.2mg/L
Depo-Provera
State
Solid
Depo-Provera
LogP
3.606
Depo-Provera
Dosage Forms
Tablets; Depo injection
Depo-Provera
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Depo-Provera
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Depo-Provera
Absorption
Rapidly absorbed from GI tract
Depo-Provera
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Depo-Provera
Patient Information
Depo-Provera
Organisms Affected
Humans and other mammals