Progestasert
Brand names,
Progestasert
Analogs
Progestasert
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Progestasert
Chemical_Formula
C22H32O3
Progestasert
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Progestasert
fda sheet
Progestasert
msds (material safety sheet)
Progestasert
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Progestasert
Molecular Weight
344.488 g/mol
Progestasert
Melting Point
220 - 223.5 oC
Progestasert
H2O Solubility
22.2mg/L
Progestasert
State
Solid
Progestasert
LogP
3.606
Progestasert
Dosage Forms
Tablets; Depo injection
Progestasert
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Progestasert
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Progestasert
Absorption
Rapidly absorbed from GI tract
Progestasert
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Progestasert
Patient Information
Progestasert
Organisms Affected
Humans and other mammals