Medroxyprogesterone Base
Brand names,
Medroxyprogesterone Base
Analogs
Medroxyprogesterone Base
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Medroxyprogesterone Base
Chemical_Formula
C22H32O3
Medroxyprogesterone Base
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Medroxyprogesterone Base
fda sheet
Medroxyprogesterone Base
msds (material safety sheet)
Medroxyprogesterone Base
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Medroxyprogesterone Base
Molecular Weight
344.488 g/mol
Medroxyprogesterone Base
Melting Point
220 - 223.5 oC
Medroxyprogesterone Base
H2O Solubility
22.2mg/L
Medroxyprogesterone Base
State
Solid
Medroxyprogesterone Base
LogP
3.606
Medroxyprogesterone Base
Dosage Forms
Tablets; Depo injection
Medroxyprogesterone Base
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Medroxyprogesterone Base
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Medroxyprogesterone Base
Absorption
Rapidly absorbed from GI tract
Medroxyprogesterone Base
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Medroxyprogesterone Base
Patient Information
Medroxyprogesterone Base
Organisms Affected
Humans and other mammals