Colirest
Brand names,
Colirest
Analogs
Colirest
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Colirest
Chemical_Formula
C22H32O3
Colirest
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Colirest
fda sheet
Colirest
msds (material safety sheet)
Colirest
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Colirest
Molecular Weight
344.488 g/mol
Colirest
Melting Point
220 - 223.5 oC
Colirest
H2O Solubility
22.2mg/L
Colirest
State
Solid
Colirest
LogP
3.606
Colirest
Dosage Forms
Tablets; Depo injection
Colirest
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Colirest
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Colirest
Absorption
Rapidly absorbed from GI tract
Colirest
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Colirest
Patient Information
Colirest
Organisms Affected
Humans and other mammals