Hematrol
Brand names,
Hematrol
Analogs
Hematrol
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Hematrol
Chemical_Formula
C22H32O3
Hematrol
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Hematrol
fda sheet
Hematrol
msds (material safety sheet)
Hematrol
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Hematrol
Molecular Weight
344.488 g/mol
Hematrol
Melting Point
220 - 223.5 oC
Hematrol
H2O Solubility
22.2mg/L
Hematrol
State
Solid
Hematrol
LogP
3.606
Hematrol
Dosage Forms
Tablets; Depo injection
Hematrol
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Hematrol
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Hematrol
Absorption
Rapidly absorbed from GI tract
Hematrol
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Hematrol
Patient Information
Hematrol
Organisms Affected
Humans and other mammals