Depo-Progestin
Brand names,
Depo-Progestin
Analogs
Depo-Progestin
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Depo-Progestin
Chemical_Formula
C22H32O3
Depo-Progestin
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Depo-Progestin
fda sheet
Depo-Progestin
msds (material safety sheet)
Depo-Progestin
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Depo-Progestin
Molecular Weight
344.488 g/mol
Depo-Progestin
Melting Point
220 - 223.5 oC
Depo-Progestin
H2O Solubility
22.2mg/L
Depo-Progestin
State
Solid
Depo-Progestin
LogP
3.606
Depo-Progestin
Dosage Forms
Tablets; Depo injection
Depo-Progestin
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Depo-Progestin
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Depo-Progestin
Absorption
Rapidly absorbed from GI tract
Depo-Progestin
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Depo-Progestin
Patient Information
Depo-Progestin
Organisms Affected
Humans and other mammals