Hydroxymethylprogesterone
Brand names,
Hydroxymethylprogesterone
Analogs
Hydroxymethylprogesterone
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Hydroxymethylprogesterone
Chemical_Formula
C22H32O3
Hydroxymethylprogesterone
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Hydroxymethylprogesterone
fda sheet
Hydroxymethylprogesterone
msds (material safety sheet)
Hydroxymethylprogesterone
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Hydroxymethylprogesterone
Molecular Weight
344.488 g/mol
Hydroxymethylprogesterone
Melting Point
220 - 223.5 oC
Hydroxymethylprogesterone
H2O Solubility
22.2mg/L
Hydroxymethylprogesterone
State
Solid
Hydroxymethylprogesterone
LogP
3.606
Hydroxymethylprogesterone
Dosage Forms
Tablets; Depo injection
Hydroxymethylprogesterone
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Hydroxymethylprogesterone
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Hydroxymethylprogesterone
Absorption
Rapidly absorbed from GI tract
Hydroxymethylprogesterone
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Hydroxymethylprogesterone
Patient Information
Hydroxymethylprogesterone
Organisms Affected
Humans and other mammals