Depo-Promone
Brand names,
Depo-Promone
Analogs
Depo-Promone
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Depo-Promone
Chemical_Formula
C22H32O3
Depo-Promone
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Depo-Promone
fda sheet
Depo-Promone
msds (material safety sheet)
Depo-Promone
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Depo-Promone
Molecular Weight
344.488 g/mol
Depo-Promone
Melting Point
220 - 223.5 oC
Depo-Promone
H2O Solubility
22.2mg/L
Depo-Promone
State
Solid
Depo-Promone
LogP
3.606
Depo-Promone
Dosage Forms
Tablets; Depo injection
Depo-Promone
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Depo-Promone
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Depo-Promone
Absorption
Rapidly absorbed from GI tract
Depo-Promone
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Depo-Promone
Patient Information
Depo-Promone
Organisms Affected
Humans and other mammals