Prempro/Premphase en es it fr

Prempro/Premphase Brand names, Prempro/Premphase Analogs

Prempro/Premphase Brand Names Mixture

  • Prempro (conjugated estrogens + medroxyprogesteron)

Prempro/Premphase Chemical_Formula


Prempro/Premphase RX_link

Prempro/Premphase fda sheet

Prempro/Premphase FDA

Prempro/Premphase msds (material safety sheet)

Prempro/Premphase MSDS

Prempro/Premphase Synthesis Reference

Bates, Cohen, U.S. Pat. 2,565,115 (1951)

Prempro/Premphase Molecular Weight

372.412 g/mol

Prempro/Premphase Melting Point

173 oC

Prempro/Premphase H2O Solubility

0.0036 mg/ml

Prempro/Premphase State


Prempro/Premphase LogP

No information avaliable

Prempro/Premphase Dosage Forms

Tablet; Injection; Vaginal cream; Topical gel

Prempro/Premphase Indication

For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)

Prempro/Premphase Pharmacology

Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.

Prempro/Premphase Absorption

Well absorbed

Prempro/Premphase side effects and Toxicity

Nausea and vomiting

Prempro/Premphase Patient Information

Prempro/Premphase Organisms Affected

Humans and other mammals