Nadigest
Brand names,
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Analogs
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Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
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Chemical_Formula
C22H32O3
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RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
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Molecular Weight
344.488 g/mol
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Melting Point
220 - 223.5 oC
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H2O Solubility
22.2mg/L
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State
Solid
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LogP
3.606
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Dosage Forms
Tablets; Depo injection
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Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
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Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
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Absorption
Rapidly absorbed from GI tract
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side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
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Patient Information
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Organisms Affected
Humans and other mammals