Metigestrona
Brand names,
Metigestrona
Analogs
Metigestrona
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Metigestrona
Chemical_Formula
C22H32O3
Metigestrona
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Metigestrona
fda sheet
Metigestrona
msds (material safety sheet)
Metigestrona
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Metigestrona
Molecular Weight
344.488 g/mol
Metigestrona
Melting Point
220 - 223.5 oC
Metigestrona
H2O Solubility
22.2mg/L
Metigestrona
State
Solid
Metigestrona
LogP
3.606
Metigestrona
Dosage Forms
Tablets; Depo injection
Metigestrona
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Metigestrona
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Metigestrona
Absorption
Rapidly absorbed from GI tract
Metigestrona
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Metigestrona
Patient Information
Metigestrona
Organisms Affected
Humans and other mammals