Meprate
Brand names,
Meprate
Analogs
Meprate
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Meprate
Chemical_Formula
C22H32O3
Meprate
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Meprate
fda sheet
Meprate
msds (material safety sheet)
Meprate
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Meprate
Molecular Weight
344.488 g/mol
Meprate
Melting Point
220 - 223.5 oC
Meprate
H2O Solubility
22.2mg/L
Meprate
State
Solid
Meprate
LogP
3.606
Meprate
Dosage Forms
Tablets; Depo injection
Meprate
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Meprate
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Meprate
Absorption
Rapidly absorbed from GI tract
Meprate
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Meprate
Patient Information
Meprate
Organisms Affected
Humans and other mammals