Sirprogen
Brand names,
Sirprogen
Analogs
Sirprogen
Brand Names Mixture
- Lunelle (Medroxyprogesterone + Estradiol)
Sirprogen
Chemical_Formula
C22H32O3
Sirprogen
RX_link
http://www.rxlist.com/cgi/generic/medrox.htm
Sirprogen
fda sheet
Sirprogen
msds (material safety sheet)
Sirprogen
Synthesis Reference
P. Ruggieri, C. Ferrari, U.S. Pat. 3,043,832 (1962)
Sirprogen
Molecular Weight
344.488 g/mol
Sirprogen
Melting Point
220 - 223.5 oC
Sirprogen
H2O Solubility
22.2mg/L
Sirprogen
State
Solid
Sirprogen
LogP
3.606
Sirprogen
Dosage Forms
Tablets; Depo injection
Sirprogen
Indication
Used as a contraceptive and to treat amenorrhea, abnormal uterine bleeding, endometriosis, endometrial and renal cell carcinomas, and pulmonary disorders such as chronic obstructive pulmonary disease (COPD), Pickwickian syndrome, and other hypercapnic pulmonary conditions.
Sirprogen
Pharmacology
Medroxyprogesterone is a synthetic progestin more potent than progesterone.
Sirprogen
Absorption
Rapidly absorbed from GI tract
Sirprogen
side effects and Toxicity
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
Sirprogen
Patient Information
Sirprogen
Organisms Affected
Humans and other mammals