Gastro
Category
Gastro Brand names, Gastro Analogs
Gastro Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Gastro Chemical_Formula
C13H22N4O3S
Gastro RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Gastro fda sheet
Gastro msds (material safety sheet)
Gastro Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Gastro Molecular Weight
314.405 g/mol
Gastro Melting Point
69-70 oC
Gastro H2O Solubility
24.7 mg/mL
Gastro State
Solid
Gastro LogP
1.93
Gastro Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Gastro Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Gastro Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Gastro Absorption
Approximately 50% bioavailability orally.
Gastro Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Gastro Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Gastro Organisms Affected
Humans and other mammals
