Ranic
Category
Ranic Brand names, Ranic Analogs
Ranic Brand Names Mixture
No information avaliable
Ranic Chemical_Formula
C15H14ClN3O4S
Ranic RX_link
http://www.rxlist.com/cgi/generic/cefaclor.htm
Ranic fda sheet
Ranic msds (material safety sheet)
Ranic Synthesis Reference
R. R. Chauvette, U.S. Pat. 3,925,372 (1975)
Ranic Molecular Weight
367.808 g/mol
Ranic Melting Point
327 oC
Ranic H2O Solubility
8.6 mg/mL
Ranic State
Solid
Ranic LogP
0.517
Ranic Dosage Forms
Capsule; Powder; Powder for solution; Powder for suspension; Suspension
Ranic Indication
For the treatment of certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.
Ranic Pharmacology
Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins. In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-wall synthesis. Cefaclor has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections: Gram positive aerobes - Staphylococci (including coagulase-positive, coagulase-negative, and penicillinase-producing strains), Streptococcus pneumoniae, and Streptococcus pyogenes (group A ß-hemolytic streptococci). Gram-negative aerobes - Escherichia coli, Haemophilus influenzae (including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.
Ranic Absorption
Well absorbed after oral administration, independent of food intake.
Ranic Toxicity
Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
Ranic Patient Information
Patients should be counseled that antibacterial drugs including Ceclor should only be used to treat bacterial
infections. They do not treat viral infections (e.g., the common cold). When Ceclor is prescribed to treat a
bacterial infection, patients should be told that although it is common to feel better early in the course of
therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of
therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria
will develop resistance and will not be treatable by Ceclor or other antibacterial drugs in the future.
Ranic Organisms Affected
Enteric bacteria and other eubacteria