Ranitidin_Helvepharm
Category
Ranitidin_Helvepharm Brand names, Ranitidin_Helvepharm Analogs
Ranitidin_Helvepharm Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidin_Helvepharm Chemical_Formula
C13H22N4O3S
Ranitidin_Helvepharm RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin_Helvepharm fda sheet
Ranitidin_Helvepharm msds (material safety sheet)
Ranitidin_Helvepharm Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin_Helvepharm Molecular Weight
314.405 g/mol
Ranitidin_Helvepharm Melting Point
69-70 oC
Ranitidin_Helvepharm H2O Solubility
24.7 mg/mL
Ranitidin_Helvepharm State
Solid
Ranitidin_Helvepharm LogP
1.93
Ranitidin_Helvepharm Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin_Helvepharm Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin_Helvepharm Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin_Helvepharm Absorption
Approximately 50% bioavailability orally.
Ranitidin_Helvepharm Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin_Helvepharm Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin_Helvepharm Organisms Affected
Humans and other mammals