Radin
Category
Radin Brand names, Radin Analogs
Radin Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Radin Chemical_Formula
C13H22N4O3S
Radin RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Radin fda sheet
Radin msds (material safety sheet)
Radin Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Radin Molecular Weight
314.405 g/mol
Radin Melting Point
69-70 oC
Radin H2O Solubility
24.7 mg/mL
Radin State
Solid
Radin LogP
1.93
Radin Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Radin Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Radin Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Radin Absorption
Approximately 50% bioavailability orally.
Radin Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Radin Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Radin Organisms Affected
Humans and other mammals
