Rani_2
Category
Rani_2 Brand names, Rani_2 Analogs
Rani_2 Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Rani_2 Chemical_Formula
C13H22N4O3S
Rani_2 RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Rani_2 fda sheet
Rani_2 msds (material safety sheet)
Rani_2 Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Rani_2 Molecular Weight
314.405 g/mol
Rani_2 Melting Point
69-70 oC
Rani_2 H2O Solubility
24.7 mg/mL
Rani_2 State
Solid
Rani_2 LogP
1.93
Rani_2 Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Rani_2 Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Rani_2 Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Rani_2 Absorption
Approximately 50% bioavailability orally.
Rani_2 Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Rani_2 Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Rani_2 Organisms Affected
Humans and other mammals
