Noctone
Category
Noctone Brand names, Noctone Analogs
Noctone Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Noctone Chemical_Formula
C13H22N4O3S
Noctone RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Noctone fda sheet
Noctone msds (material safety sheet)
Noctone Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Noctone Molecular Weight
314.405 g/mol
Noctone Melting Point
69-70 oC
Noctone H2O Solubility
24.7 mg/mL
Noctone State
Solid
Noctone LogP
1.93
Noctone Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Noctone Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Noctone Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Noctone Absorption
Approximately 50% bioavailability orally.
Noctone side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Noctone Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Noctone Organisms Affected
Humans and other mammals
