Ranitidin_Normon
Category
Ranitidin_Normon Brand names, Ranitidin_Normon Analogs
Ranitidin_Normon Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidin_Normon Chemical_Formula
C13H22N4O3S
Ranitidin_Normon RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin_Normon fda sheet
Ranitidin_Normon msds (material safety sheet)
Ranitidin_Normon Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin_Normon Molecular Weight
314.405 g/mol
Ranitidin_Normon Melting Point
69-70 oC
Ranitidin_Normon H2O Solubility
24.7 mg/mL
Ranitidin_Normon State
Solid
Ranitidin_Normon LogP
1.93
Ranitidin_Normon Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin_Normon Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin_Normon Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin_Normon Absorption
Approximately 50% bioavailability orally.
Ranitidin_Normon Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin_Normon Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin_Normon Organisms Affected
Humans and other mammals
