Ranitidin_NM
Category
Ranitidin_NM Brand names, Ranitidin_NM Analogs
Ranitidin_NM Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidin_NM Chemical_Formula
C13H22N4O3S
Ranitidin_NM RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin_NM fda sheet
Ranitidin_NM msds (material safety sheet)
Ranitidin_NM Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin_NM Molecular Weight
314.405 g/mol
Ranitidin_NM Melting Point
69-70 oC
Ranitidin_NM H2O Solubility
24.7 mg/mL
Ranitidin_NM State
Solid
Ranitidin_NM LogP
1.93
Ranitidin_NM Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin_NM Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin_NM Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin_NM Absorption
Approximately 50% bioavailability orally.
Ranitidin_NM Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin_NM Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin_NM Organisms Affected
Humans and other mammals
