Rani_AbZ
Category
Rani_AbZ Brand names, Rani_AbZ Analogs
Rani_AbZ Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Rani_AbZ Chemical_Formula
C13H22N4O3S
Rani_AbZ RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Rani_AbZ fda sheet
Rani_AbZ msds (material safety sheet)
Rani_AbZ Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Rani_AbZ Molecular Weight
314.405 g/mol
Rani_AbZ Melting Point
69-70 oC
Rani_AbZ H2O Solubility
24.7 mg/mL
Rani_AbZ State
Solid
Rani_AbZ LogP
1.93
Rani_AbZ Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Rani_AbZ Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Rani_AbZ Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Rani_AbZ Absorption
Approximately 50% bioavailability orally.
Rani_AbZ Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Rani_AbZ Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Rani_AbZ Organisms Affected
Humans and other mammals
