Ranitidine_HCL
Category
Ranitidine_HCL Brand names, Ranitidine_HCL Analogs
Ranitidine_HCL Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidine_HCL Chemical_Formula
C13H22N4O3S
Ranitidine_HCL RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidine_HCL fda sheet
Ranitidine_HCL msds (material safety sheet)
Ranitidine_HCL Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidine_HCL Molecular Weight
314.405 g/mol
Ranitidine_HCL Melting Point
69-70 oC
Ranitidine_HCL H2O Solubility
24.7 mg/mL
Ranitidine_HCL State
Solid
Ranitidine_HCL LogP
1.93
Ranitidine_HCL Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidine_HCL Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidine_HCL Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidine_HCL Absorption
Approximately 50% bioavailability orally.
Ranitidine_HCL Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidine_HCL Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidine_HCL Organisms Affected
Humans and other mammals
