Label
Category
Label Brand names, Label Analogs
Label Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Label Chemical_Formula
C13H22N4O3S
Label RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Label fda sheet
Label msds (material safety sheet)
Label Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Label Molecular Weight
314.405 g/mol
Label Melting Point
69-70 oC
Label H2O Solubility
24.7 mg/mL
Label State
Solid
Label LogP
1.93
Label Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Label Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Label Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Label Absorption
Approximately 50% bioavailability orally.
Label Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Label Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Label Organisms Affected
Humans and other mammals
