Ranitidine_hydrochloride

Category

Ranitidine_hydrochloride




Useful info

Ranitidine_hydrochloride Brand names, Ranitidine_hydrochloride Analogs

Ranitidine_hydrochloride Brand Names Mixture

  • Tritec (ranitidine bismuth citrate salt)

    • Ranitidine_hydrochloride Chemical_Formula

    C13H22N4O3S

    Ranitidine_hydrochloride RX_link

    http://www.rxlist.com/cgi/generic2/ranitbc.htm

    Ranitidine_hydrochloride fda sheet

    Ranitidine_hydrochloride FDA

    Ranitidine_hydrochloride msds (material safety sheet)

    Ranitidine_hydrochloride MSDS

    Ranitidine_hydrochloride Synthesis Reference

    B. J. Price et al., U.S. Pat. 4,128,658 (1978)

    Ranitidine_hydrochloride Molecular Weight

    314.405 g/mol

    Ranitidine_hydrochloride Melting Point

    69-70 oC

    Ranitidine_hydrochloride H2O Solubility

    24.7 mg/mL

    Ranitidine_hydrochloride State

    Solid

    Ranitidine_hydrochloride LogP

    1.93

    Ranitidine_hydrochloride Dosage Forms

    Capsule; Liquid; Solution; Tablet; Syrup

    Ranitidine_hydrochloride Indication

    Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).

    Ranitidine_hydrochloride Pharmacology

    Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.

    Ranitidine_hydrochloride Absorption

    Approximately 50% bioavailability orally.

    Ranitidine_hydrochloride Toxicity

    LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.

    Ranitidine_hydrochloride Patient Information

    PATIENT INFORMATION

    Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
    contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
    on the tongue.

    Ranitidine_hydrochloride Organisms Affected

    Humans and other mammals