Ranitidine_Base
Category
Ranitidine_Base Brand names, Ranitidine_Base Analogs
Ranitidine_Base Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidine_Base Chemical_Formula
C13H22N4O3S
Ranitidine_Base RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidine_Base fda sheet
Ranitidine_Base msds (material safety sheet)
Ranitidine_Base Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidine_Base Molecular Weight
314.405 g/mol
Ranitidine_Base Melting Point
69-70 oC
Ranitidine_Base H2O Solubility
24.7 mg/mL
Ranitidine_Base State
Solid
Ranitidine_Base LogP
1.93
Ranitidine_Base Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidine_Base Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidine_Base Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidine_Base Absorption
Approximately 50% bioavailability orally.
Ranitidine_Base Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidine_Base Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidine_Base Organisms Affected
Humans and other mammals
