Quadrin
Category
Quadrin Brand names, Quadrin Analogs
Quadrin Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Quadrin Chemical_Formula
C13H22N4O3S
Quadrin RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Quadrin fda sheet
Quadrin msds (material safety sheet)
Quadrin Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Quadrin Molecular Weight
314.405 g/mol
Quadrin Melting Point
69-70 oC
Quadrin H2O Solubility
24.7 mg/mL
Quadrin State
Solid
Quadrin LogP
1.93
Quadrin Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Quadrin Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Quadrin Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Quadrin Absorption
Approximately 50% bioavailability orally.
Quadrin Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Quadrin Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Quadrin Organisms Affected
Humans and other mammals
