Noktome
Category
Noktome Brand names, Noktome Analogs
Noktome Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Noktome Chemical_Formula
C13H22N4O3S
Noktome RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Noktome fda sheet
Noktome msds (material safety sheet)
Noktome Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Noktome Molecular Weight
314.405 g/mol
Noktome Melting Point
69-70 oC
Noktome H2O Solubility
24.7 mg/mL
Noktome State
Solid
Noktome LogP
1.93
Noktome Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Noktome Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Noktome Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Noktome Absorption
Approximately 50% bioavailability orally.
Noktome Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Noktome Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Noktome Organisms Affected
Humans and other mammals
