Ranitidin_PB
Category
Ranitidin_PB Brand names, Ranitidin_PB Analogs
Ranitidin_PB Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidin_PB Chemical_Formula
C13H22N4O3S
Ranitidin_PB RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin_PB fda sheet
Ranitidin_PB msds (material safety sheet)
Ranitidin_PB Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin_PB Molecular Weight
314.405 g/mol
Ranitidin_PB Melting Point
69-70 oC
Ranitidin_PB H2O Solubility
24.7 mg/mL
Ranitidin_PB State
Solid
Ranitidin_PB LogP
1.93
Ranitidin_PB Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin_PB Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin_PB Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin_PB Absorption
Approximately 50% bioavailability orally.
Ranitidin_PB Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin_PB Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin_PB Organisms Affected
Humans and other mammals
