Ranitidin_AWD
Category
Ranitidin_AWD Brand names, Ranitidin_AWD Analogs
Ranitidin_AWD Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidin_AWD Chemical_Formula
C13H22N4O3S
Ranitidin_AWD RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin_AWD fda sheet
Ranitidin_AWD msds (material safety sheet)
Ranitidin_AWD Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin_AWD Molecular Weight
314.405 g/mol
Ranitidin_AWD Melting Point
69-70 oC
Ranitidin_AWD H2O Solubility
24.7 mg/mL
Ranitidin_AWD State
Solid
Ranitidin_AWD LogP
1.93
Ranitidin_AWD Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin_AWD Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin_AWD Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin_AWD Absorption
Approximately 50% bioavailability orally.
Ranitidin_AWD Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin_AWD Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin_AWD Organisms Affected
Humans and other mammals
