Ranitic
Category
Ranitic Brand names, Ranitic Analogs
Ranitic Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitic Chemical_Formula
C13H22N4O3S
Ranitic RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitic fda sheet
Ranitic msds (material safety sheet)
Ranitic Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitic Molecular Weight
314.405 g/mol
Ranitic Melting Point
69-70 oC
Ranitic H2O Solubility
24.7 mg/mL
Ranitic State
Solid
Ranitic LogP
1.93
Ranitic Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitic Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitic Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitic Absorption
Approximately 50% bioavailability orally.
Ranitic Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitic Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitic Organisms Affected
Humans and other mammals
