Ranitidin_Arcana
Category
Ranitidin_Arcana Brand names, Ranitidin_Arcana Analogs
Ranitidin_Arcana Brand Names Mixture
Tritec (ranitidine bismuth citrate salt)
Ranitidin_Arcana Chemical_Formula
C13H22N4O3S
Ranitidin_Arcana RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin_Arcana fda sheet
Ranitidin_Arcana msds (material safety sheet)
Ranitidin_Arcana Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin_Arcana Molecular Weight
314.405 g/mol
Ranitidin_Arcana Melting Point
69-70 oC
Ranitidin_Arcana H2O Solubility
24.7 mg/mL
Ranitidin_Arcana State
Solid
Ranitidin_Arcana LogP
1.93
Ranitidin_Arcana Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin_Arcana Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin_Arcana Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin_Arcana Absorption
Approximately 50% bioavailability orally.
Ranitidin_Arcana Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin_Arcana Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin_Arcana Organisms Affected
Humans and other mammals
