Ranitidine HCl (Form I And Form Ii)
Brand names,
Ranitidine HCl (Form I And Form Ii)
Analogs
Ranitidine HCl (Form I And Form Ii)
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Ranitidine HCl (Form I And Form Ii)
Chemical_Formula
C13H22N4O3S
Ranitidine HCl (Form I And Form Ii)
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidine HCl (Form I And Form Ii)
fda sheet
Ranitidine HCl (Form I And Form Ii)
msds (material safety sheet)
Ranitidine HCl (Form I And Form Ii)
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidine HCl (Form I And Form Ii)
Molecular Weight
314.405 g/mol
Ranitidine HCl (Form I And Form Ii)
Melting Point
69-70 oC
Ranitidine HCl (Form I And Form Ii)
H2O Solubility
24.7 mg/mL
Ranitidine HCl (Form I And Form Ii)
State
Solid
Ranitidine HCl (Form I And Form Ii)
LogP
1.93
Ranitidine HCl (Form I And Form Ii)
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidine HCl (Form I And Form Ii)
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidine HCl (Form I And Form Ii)
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidine HCl (Form I And Form Ii)
Absorption
Approximately 50% bioavailability orally.
Ranitidine HCl (Form I And Form Ii)
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidine HCl (Form I And Form Ii)
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidine HCl (Form I And Form Ii)
Organisms Affected
Humans and other mammals