Ranidine

Ranidine Brand names, Ranidine Analogs

Ranidine Brand Names Mixture

Tritec (ranitidine bismuth citrate salt)

Ranidine Chemical_Formula

C₁₃H₂₂N₄O₃S

Ranidine RX_link

http://www.rxlist.com/cgi/generic2/ranitbc.htm

Ranidine fda sheet

Ranidine FDA

Ranidine msds (material safety sheet)

Ranidine MSDS

Ranidine Synthesis Reference

B. J. Price et al., U.S. Pat. 4,128,658 (1978)

Ranidine Molecular Weight

314.405 g/mol

Ranidine Melting Point

69-70 ^oC

Ranidine H₂O Solubility

24.7 mg/mL

Ranidine State

Solid

Ranidine LogP

1.93

Ranidine Dosage Forms

Capsule; Liquid; Solution; Tablet; Syrup

Ranidine Indication

Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).

Ranidine Pharmacology

Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.

Ranidine Absorption

Approximately 50% bioavailability orally.

Ranidine side effects and Toxicity

LD₅₀=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.

Ranidine Patient Information

PATIENT INFORMATION

Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.

Ranidine Organisms Affected

Humans and other mammals