Ranisan
Brand names,
Ranisan
Analogs
Ranisan
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Ranisan
Chemical_Formula
C13H22N4O3S
Ranisan
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranisan
fda sheet
Ranisan
msds (material safety sheet)
Ranisan
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranisan
Molecular Weight
314.405 g/mol
Ranisan
Melting Point
69-70 oC
Ranisan
H2O Solubility
24.7 mg/mL
Ranisan
State
Solid
Ranisan
LogP
1.93
Ranisan
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranisan
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranisan
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranisan
Absorption
Approximately 50% bioavailability orally.
Ranisan
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranisan
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranisan
Organisms Affected
Humans and other mammals