PharmacyCodes



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Trigger Brand names, Trigger Analogs

Trigger Brand Names Mixture

  • Tritec (ranitidine bismuth citrate salt)

Trigger Chemical_Formula

C13H22N4O3S

Trigger RX_link

http://www.rxlist.com/cgi/generic2/ranitbc.htm

Trigger fda sheet

Trigger FDA

Trigger msds (material safety sheet)

Trigger MSDS

Trigger Synthesis Reference

B. J. Price et al., U.S. Pat. 4,128,658 (1978)

Trigger Molecular Weight

314.405 g/mol

Trigger Melting Point

69-70 oC

Trigger H2O Solubility

24.7 mg/mL

Trigger State

Solid

Trigger LogP

1.93

Trigger Dosage Forms

Capsule; Liquid; Solution; Tablet; Syrup

Trigger Indication

Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).

Trigger Pharmacology

Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.

Trigger Absorption

Approximately 50% bioavailability orally.

Trigger side effects and Toxicity

LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.

Trigger Patient Information

PATIENT INFORMATION

Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.

Trigger Organisms Affected

Humans and other mammals