Ranitidin Hexal
Brand names,
Ranitidin Hexal
Analogs
Ranitidin Hexal
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Ranitidin Hexal
Chemical_Formula
C13H22N4O3S
Ranitidin Hexal
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin Hexal
fda sheet
Ranitidin Hexal
msds (material safety sheet)
Ranitidin Hexal
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin Hexal
Molecular Weight
314.405 g/mol
Ranitidin Hexal
Melting Point
69-70 oC
Ranitidin Hexal
H2O Solubility
24.7 mg/mL
Ranitidin Hexal
State
Solid
Ranitidin Hexal
LogP
1.93
Ranitidin Hexal
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin Hexal
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin Hexal
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin Hexal
Absorption
Approximately 50% bioavailability orally.
Ranitidin Hexal
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin Hexal
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin Hexal
Organisms Affected
Humans and other mammals