Ranitidin-Isis
Brand names,
Ranitidin-Isis
Analogs
Ranitidin-Isis
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Ranitidin-Isis
Chemical_Formula
C13H22N4O3S
Ranitidin-Isis
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin-Isis
fda sheet
Ranitidin-Isis
msds (material safety sheet)
Ranitidin-Isis
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin-Isis
Molecular Weight
314.405 g/mol
Ranitidin-Isis
Melting Point
69-70 oC
Ranitidin-Isis
H2O Solubility
24.7 mg/mL
Ranitidin-Isis
State
Solid
Ranitidin-Isis
LogP
1.93
Ranitidin-Isis
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin-Isis
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin-Isis
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin-Isis
Absorption
Approximately 50% bioavailability orally.
Ranitidin-Isis
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin-Isis
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin-Isis
Organisms Affected
Humans and other mammals