Ranitidine hydrochloride (JP14/USP)
Brand names,
Ranitidine hydrochloride (JP14/USP)
Analogs
Ranitidine hydrochloride (JP14/USP)
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Ranitidine hydrochloride (JP14/USP)
Chemical_Formula
C13H22N4O3S
Ranitidine hydrochloride (JP14/USP)
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidine hydrochloride (JP14/USP)
fda sheet
Ranitidine hydrochloride (JP14/USP)
msds (material safety sheet)
Ranitidine hydrochloride (JP14/USP)
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidine hydrochloride (JP14/USP)
Molecular Weight
314.405 g/mol
Ranitidine hydrochloride (JP14/USP)
Melting Point
69-70 oC
Ranitidine hydrochloride (JP14/USP)
H2O Solubility
24.7 mg/mL
Ranitidine hydrochloride (JP14/USP)
State
Solid
Ranitidine hydrochloride (JP14/USP)
LogP
1.93
Ranitidine hydrochloride (JP14/USP)
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidine hydrochloride (JP14/USP)
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidine hydrochloride (JP14/USP)
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidine hydrochloride (JP14/USP)
Absorption
Approximately 50% bioavailability orally.
Ranitidine hydrochloride (JP14/USP)
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidine hydrochloride (JP14/USP)
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidine hydrochloride (JP14/USP)
Organisms Affected
Humans and other mammals