Raniben
Brand names,
Raniben
Analogs
Raniben
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Raniben
Chemical_Formula
C13H22N4O3S
Raniben
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Raniben
fda sheet
Raniben
msds (material safety sheet)
Raniben
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Raniben
Molecular Weight
314.405 g/mol
Raniben
Melting Point
69-70 oC
Raniben
H2O Solubility
24.7 mg/mL
Raniben
State
Solid
Raniben
LogP
1.93
Raniben
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Raniben
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Raniben
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Raniben
Absorption
Approximately 50% bioavailability orally.
Raniben
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Raniben
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Raniben
Organisms Affected
Humans and other mammals