Ranitidin Atid
Brand names,
Ranitidin Atid
Analogs
Ranitidin Atid
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Ranitidin Atid
Chemical_Formula
C13H22N4O3S
Ranitidin Atid
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Ranitidin Atid
fda sheet
Ranitidin Atid
msds (material safety sheet)
Ranitidin Atid
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Ranitidin Atid
Molecular Weight
314.405 g/mol
Ranitidin Atid
Melting Point
69-70 oC
Ranitidin Atid
H2O Solubility
24.7 mg/mL
Ranitidin Atid
State
Solid
Ranitidin Atid
LogP
1.93
Ranitidin Atid
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Ranitidin Atid
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidin Atid
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Ranitidin Atid
Absorption
Approximately 50% bioavailability orally.
Ranitidin Atid
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Ranitidin Atid
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Ranitidin Atid
Organisms Affected
Humans and other mammals