Zantac 150
Brand names,
Zantac 150
Analogs
Zantac 150
Brand Names Mixture
- Tritec (ranitidine bismuth citrate salt)
Zantac 150
Chemical_Formula
C13H22N4O3S
Zantac 150
RX_link
http://www.rxlist.com/cgi/generic2/ranitbc.htm
Zantac 150
fda sheet
Zantac 150
msds (material safety sheet)
Zantac 150
Synthesis Reference
B. J. Price et al., U.S. Pat. 4,128,658 (1978)
Zantac 150
Molecular Weight
314.405 g/mol
Zantac 150
Melting Point
69-70 oC
Zantac 150
H2O Solubility
24.7 mg/mL
Zantac 150
State
Solid
Zantac 150
LogP
1.93
Zantac 150
Dosage Forms
Capsule; Liquid; Solution; Tablet; Syrup
Zantac 150
Indication
Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Zantac 150
Pharmacology
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Zantac 150
Absorption
Approximately 50% bioavailability orally.
Zantac 150
side effects and Toxicity
LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Zantac 150
Patient Information
PATIENT INFORMATION
Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets
contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved
on the tongue.
Zantac 150
Organisms Affected
Humans and other mammals