Vesparaz-Wirkstoff
Brand names,
Vesparaz-Wirkstoff
Analogs
Vesparaz-Wirkstoff
Brand Names Mixture
Vesparaz-Wirkstoff
Chemical_Formula
C21H27ClN2O2
Vesparaz-Wirkstoff
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Vesparaz-Wirkstoff
fda sheet
Vesparaz-Wirkstoff
msds (material safety sheet)
Vesparaz-Wirkstoff
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Vesparaz-Wirkstoff
Molecular Weight
374.904 g/mol
Vesparaz-Wirkstoff
Melting Point
190 oC
Vesparaz-Wirkstoff
H2O Solubility
< 700 mg/mL
Vesparaz-Wirkstoff
State
Solid
Vesparaz-Wirkstoff
LogP
3.036
Vesparaz-Wirkstoff
Dosage Forms
Capsule; Liquid; Solution; Syrup
Vesparaz-Wirkstoff
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Vesparaz-Wirkstoff
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Vesparaz-Wirkstoff
Absorption
Rapidly absorbed from the gastrointestinal tract
Vesparaz-Wirkstoff
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Vesparaz-Wirkstoff
Patient Information
Vesparaz-Wirkstoff
Organisms Affected
Humans and other mammals