Hydroxyzin
Brand names,
Hydroxyzin
Analogs
Hydroxyzin
Brand Names Mixture
Hydroxyzin
Chemical_Formula
C21H27ClN2O2
Hydroxyzin
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxyzin
fda sheet
Hydroxyzin
msds (material safety sheet)
Hydroxyzin
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxyzin
Molecular Weight
374.904 g/mol
Hydroxyzin
Melting Point
190 oC
Hydroxyzin
H2O Solubility
< 700 mg/mL
Hydroxyzin
State
Solid
Hydroxyzin
LogP
3.036
Hydroxyzin
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxyzin
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxyzin
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxyzin
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxyzin
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxyzin
Patient Information
Hydroxyzin
Organisms Affected
Humans and other mammals