Atarax
Brand names,
Atarax
Analogs
Atarax
Brand Names Mixture
Atarax
Chemical_Formula
C21H27ClN2O2
Atarax
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Atarax
fda sheet
Atarax
msds (material safety sheet)
Atarax
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Atarax
Molecular Weight
374.904 g/mol
Atarax
Melting Point
190 oC
Atarax
H2O Solubility
< 700 mg/mL
Atarax
State
Solid
Atarax
LogP
3.036
Atarax
Dosage Forms
Capsule; Liquid; Solution; Syrup
Atarax
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Atarax
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Atarax
Absorption
Rapidly absorbed from the gastrointestinal tract
Atarax
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Atarax
Patient Information
Atarax
Organisms Affected
Humans and other mammals