Atarazoid
Brand names,
Atarazoid
Analogs
Atarazoid
Brand Names Mixture
Atarazoid
Chemical_Formula
C21H27ClN2O2
Atarazoid
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Atarazoid
fda sheet
Atarazoid
msds (material safety sheet)
Atarazoid
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Atarazoid
Molecular Weight
374.904 g/mol
Atarazoid
Melting Point
190 oC
Atarazoid
H2O Solubility
< 700 mg/mL
Atarazoid
State
Solid
Atarazoid
LogP
3.036
Atarazoid
Dosage Forms
Capsule; Liquid; Solution; Syrup
Atarazoid
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Atarazoid
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Atarazoid
Absorption
Rapidly absorbed from the gastrointestinal tract
Atarazoid
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Atarazoid
Patient Information
Atarazoid
Organisms Affected
Humans and other mammals