Traquizine
Brand names,
Traquizine
Analogs
Traquizine
Brand Names Mixture
Traquizine
Chemical_Formula
C21H27ClN2O2
Traquizine
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Traquizine
fda sheet
Traquizine
msds (material safety sheet)
Traquizine
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Traquizine
Molecular Weight
374.904 g/mol
Traquizine
Melting Point
190 oC
Traquizine
H2O Solubility
< 700 mg/mL
Traquizine
State
Solid
Traquizine
LogP
3.036
Traquizine
Dosage Forms
Capsule; Liquid; Solution; Syrup
Traquizine
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Traquizine
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Traquizine
Absorption
Rapidly absorbed from the gastrointestinal tract
Traquizine
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Traquizine
Patient Information
Traquizine
Organisms Affected
Humans and other mammals