Hydroxizine
Brand names,
Hydroxizine
Analogs
Hydroxizine
Brand Names Mixture
Hydroxizine
Chemical_Formula
C21H27ClN2O2
Hydroxizine
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Hydroxizine
fda sheet
Hydroxizine
msds (material safety sheet)
Hydroxizine
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Hydroxizine
Molecular Weight
374.904 g/mol
Hydroxizine
Melting Point
190 oC
Hydroxizine
H2O Solubility
< 700 mg/mL
Hydroxizine
State
Solid
Hydroxizine
LogP
3.036
Hydroxizine
Dosage Forms
Capsule; Liquid; Solution; Syrup
Hydroxizine
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Hydroxizine
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Hydroxizine
Absorption
Rapidly absorbed from the gastrointestinal tract
Hydroxizine
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Hydroxizine
Patient Information
Hydroxizine
Organisms Affected
Humans and other mammals