Fenarol
Brand names,
Fenarol
Analogs
Fenarol
Brand Names Mixture
Fenarol
Chemical_Formula
C21H27ClN2O2
Fenarol
RX_link
http://www.rxlist.com/cgi/generic/hydrox.htm
Fenarol
fda sheet
Fenarol
msds (material safety sheet)
Fenarol
Synthesis Reference
Moren; U.S. Pat. 2,899,436 (1959)
Fenarol
Molecular Weight
374.904 g/mol
Fenarol
Melting Point
190 oC
Fenarol
H2O Solubility
< 700 mg/mL
Fenarol
State
Solid
Fenarol
LogP
3.036
Fenarol
Dosage Forms
Capsule; Liquid; Solution; Syrup
Fenarol
Indication
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Fenarol
Pharmacology
Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist.
Fenarol
Absorption
Rapidly absorbed from the gastrointestinal tract
Fenarol
side effects and Toxicity
Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Fenarol
Patient Information
Fenarol
Organisms Affected
Humans and other mammals